Albumin-Bound Toxin Removal in Liver Support Devices: Case Study of Tryptophan Adsorption and Dialysis
نویسندگان
چکیده
Dialysis and adsorption processes are commonly implemented in liver support devices for the removal of albumin-bound toxins such as tryptophan. In this work, dialysis and adsorption of tryptophan from albumin-containing solutions were investigated; in particular, the effect of albumin concentration on both processes was analysed. Theoretical models accounting for albumin-tryptophan binding were proposed and fitted to the experimental data in order to obtain equilibrium and kinetic parameters. The results allowed to perform a simulation of an albumin-dialysis liver support device session and compare the performance of different dialysate recirculation/regeneration policies.
منابع مشابه
Chemical Engineeringtransactions
Simultaneous Removal of Albumin-Bound Toxins in Liver Support Devices: Bilirubin and Tryptophan Adsorption on Activated Carbon M. Cristina Annesini, Vincenzo Piemonte*, Luca Turchetti University of Rome “La Sapienza” Department of Chemical Engineering Materials & Environment, via Eudossiana 18, 00184 Rome, Italy University Campus Bio-medico of Rome Faculty of Engineering , via Alvaro del Portil...
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